What Athletes Should Know About AICAR and Others AICAr induces hypoglycemia in vivo 42,43 and the effect is abolished in mice lacking AMPK 32,33,35, suggesting that the effect can be more ascribed to AMPK-dependent entry of glucose than to AMPK-independent effects of AICAr on the inhibition of gluconeogenesis. In addition, AICAr may help to reduce peripheral resistance to insulin action because AICAr acts...